The NSBG Science Team Advantage
The NSBG Science Team consists of highly experienced pharmaceutical technology specialists with in-depth
knowledge of the possibilities, limitations and restrictions of both the contemporary pharma and
cannabis industries. The NSBG Science Team also stays current on latest drug (including cannabinoids)
delivery trends and products.
The NSBG Science Team has an excellent pharmacological understanding of processes in the living body and
the effect of drugs (including cannabinoids) on these biological processes. This allows NSBG to
significantly accelerate innovative approaches for the development of effective, targeted and safe
formulations and drug delivery systems. The formulation development usually starts from feasibility
study, followed by laboratory scale-up process development. If required, pilot, pivotal and full scale
manufacturing process can be developed. The NSBG Science Team maintains the highest scientific level
when it comes to formulation, manufacturing and technology transfer.
NSBG’s Science Team aims to get a head start on R&D, including product development and optimization, and
is working industriously to meet the high market demand to get ahead of the curve in anticipation for
the expansion of a product line (i.e. edibles, topicals, beverages, concentrates and other cannabis
products) which will be available to consumers (Fall 2019) under the Cannabis Act.
NSBG’s proprietary technologies can be effectively employed for preparation of highly absorbable
formulations containing cannabinoids, which are greatly suitable for oral, topical and transdermal
administration in different dosage forms – liquids, tablets, capsules, creams, gels, lotions, etc.
NSBG's Science Team is both familiar and knowledgeable with most major global regulations (medical and
recreational) governing various cannabis industries. Understanding applicable regulations ensures that
NSBG only develops products that are permissible within the target market (i.e. province, state, country
etc.). The cannabis industry is constantly evolving and NSBG is committed on staying current on all
Benefits and differentiation factors of NSBG’s Nanotechnology vs. other Technologies
Most of NSBG’s developed technologies are based on the incorporation of biologically active compounds
into colloidal delivery systems, where drug loaded particles have extremely small dimensions, measured
by nanometers (nm) – usually from 10 to 300 nm. This means that the particles are 20-400 times smaller
than red blood cells and roughly 1000-3000 times smaller than the diameter of human hair. Such miniscule
particles are usually absorbed very fast inside the gastro-intestinal tract when swallowed. They
effectively penetrate between the cells (paracellular way) and through the cells (intracellular way).
After absorption, the drug (which is included within delivery system) is transported into the body
protected by material of the particles.
Incorporation of biologically active compounds into colloidal delivery systems (nanoemulsion, liposomes,
nanoparticles) in most cases increases absorption several folds, especially when the component is poorly
water soluble. Use of colloidal delivery systems also allows for taste masking, targeted delivery and
improved stability of the product.
NSBG technologies are also based on pharmaceutically approved components that are safe and well
investigated. The preparation process is robust, reproducible and scalable. Additionally, NSBG’s
technologies do not use uncommon and complex equipment, making the manufacturing process suitable for
most contract and outsourced manufacturers.
NSBG technology is especially suited for cannabis-based products. (i.e. better predictability, dosing
and formulation control)
Most cannabinoids that determine the biological activity of cannabis are highly hydrophobic compounds,
which are insoluble in water and typically reasonably soluble in oils. NSBG’s technologies allow for the
development of the appropriate composition of the oil phase for emulsion or suitable combination of
components for micellar system providing high loading, excellent stability and outstanding performance
in the body. The technologies can be applied for natural products, dietary supplements, food, beverages
and for pharmaceutical or cosmeceutical preparations, creams, ointments and lotions.
How NSBG Technology Works
Active component (THC, CBD, combination of cannabinoids cannabis extracts) are completely dissolved in
an appropriate blend of physiologically acceptable lipid components, surfactants, cosurfactants and
solvents. The prepared solution at predetermined temperature is combined with the water phase,
spontaneously forming a nanoemulsion with droplets size of 10-300 nm, and the active component remains
dissolved in the oil phase of these miniscule droplets.
Due to the extremely small size, this colloidal system has excellent physical stability, and drug loaded
particles that penetrate either through gaps between cells or by endocytosis (cellular uptake),
supporting fast penetration and complete absorption.